Professor, BP Faculty Fellow in Chemical Engineering, and ABET Coordinator
For research web page click here.
Research Fellow, Surgical Services, Massachusetts General Hospital, 2001
Ph.D., Chemical Engineering, Wayne State University, 1998
M. S., Chemical Engineering, Wayne State University, 1996
B. S., Chemical Engineering, Bangalore University, 1992
MAJOR AREAS OF INTEREST
We are interested in understanding the mechanisms at the molecular level that trigger cellular processes in stem cell differentiation and proliferation, in regenerating tissues, and traumatic conditions.
RECENT RESEARCH ACTIVITIES
Reactor Design: We are interested in developing bioreactors that facilitate development of large tissues useful in clinical applications. We use computational fluid dynamic software and experiments to test and validate various configurations.
Scaffold Synthesis: We are interested in developing technologies for three dimensional porous matrix generation, useful in regenerating various soft tissues. We focus on developing synthetic substitutes mimicking natural matrices which possess the necessary biomechanical properties for tissue regenerations.
Stem Cell Based Tissue Engineering: The goal is i) to understand the influence of structural features, chemical signals, and mechanical signals on the proliferation and differentiation of stem cells from various sources which lead to the development of a 3D stem cell culture system and ii) to use these conditions in generating tissues of interest. We also compare how cells from different origins grow (and differentiate) on 3D matrices which are synthesized to mimic various microenvironments in the body.
Trauma Induced Muscle Wasting and Drug Delivery: The overall goal is i) to better understand the cause of muscle wasting and immune dysfunction and ii) to develop novel therapies aimed at preventing atherosclerosis. We are also interested in developing oral and transdermal drug delivery approaches.
Podichetty JT, Bhasker PR, Singarapu K, Madihally SV, “Multiple Approaches to Predicting Oxygen and Glucose Consumptions by HepG2 Cells on Porous Scaffolds in an Axial-Flow Bioreactor”. Biotechnology/Biongineering.112 (2), 393-404. 2015.
Walker KJ, Madihally SV, “Anisotropic Temperature Sensitive Chitosan-based Injectable Hydrogels Mimicking Cartilage Matrix”. Journal of Biomedical Materials Research-Part B.103B(6):1149-60, 2015.
H-K Lin, Madihally SV, Palmer B, Frimberger D, Fung K-M, and Kropp BP, “Biomatrices for Bladder Reconstruction”. Advanced Drug Delivery Reviews. 82-83: 47-63, 2015.
Pai KK, Singarapu K, Jacob JD, Madihally SV, “Dose Dependent Selectivity and Response of Different Types of Mammalian Cells to Surface Dielectric Barrier Discharge (SDBD) Plasma”. Plasma Processes and Polymers. 12(7):666-77, 2015.
Khalf A, Singarapu K, Madihally SV, “Cellulose Acetate Core-Shell Structured Electrospun Fiber: Fabrication and Characterization”. Cellulose 22 (2): 1389-1400. 2015.
Khalf A, Singarapu K, Madihally SV, “Influence of Solvent Characteristics in Triaxial Electrospun Fiber Formation”. Reactive and Functional Polymers. 90:36-46. 2015.
Tormos CM, Abraham C, Madihally SV, “Improving the Stability of Chitosan-Gelatin Based Hydrogels for Cell Delivery Using Transglutaminase and Controlled Release of Doxycycline”. Drug Delivery and Translational Research. 5(6): 575-584, 2015