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Research Assistant Professor, Mechanical Engineering, North Carolina State University, 2015
Research Scientist, DoD Biotechnology HPC Software Applications Institute (BHSAI), 2015
Postdoctoral Researcher, Mechanical Engineering, North Carolina State University, 2013
Ph.D., Mechanical Engineering, North Carolina State University, 2013
M.S., Mechanical Engineering, North Carolina State University, 2010
B.S., Engineering Mechanics, Zhejiang University, 2007
MAJOR AREAS OF RESEARCH
Computational Fluid-Particle Dynamics and Advanced Numerical Methods
Physiologically Based Pharmacokinetic (PBPK) Modeling
Particulate Matter Transport Phenomena
Lung Aerosol Dynamics
Pulmonary Health Risk Assessment
Pulmonary Drug Delivery Optimization
Non-invasive Pulmonary Disease Diagnosis
RECENT RESEARCH ACTIVITIES
Toxic or Therapeutic Aerosol Transport and Uptake in the Respiratory Systems and Systemic Regions
The overall goal of our group is to understand and consider more underlying physics and chemistry, and provide non-invasive, cost-effective and accurate numerical tools. We make contributions to medical world and human life by providing well-posed solutions to patient-specific pulmonary health problems using multi-scale modeling techniques. By reconstructing a subject-specific whole lung model covering the entire lung conducting zone (from mouth to generation 17), we are able to use computational fluid-particle dynamics (CFPD) and Physiologically Based Pharmacokinetic (PBPK) models to simulate the transport, deposition, translocation, and clearance of inhaled toxic or therapeutic aerosols in the pulmonary routes and systemic regions Employing our numerical model and whole-lung geometry, we will able to provide high-resolution data and perform parametric sensitivity studies for lung geometric and operational factors that affect aerosol uptakes/clearance in the human bodies under realistic breathing patterns. Flow regimes, particle transport characteristics, and lung airway deformations will be visualized. The new insights generated by the CFPD-PBPK model will be significant for multiple biomedical applications, i.e., medical device improvements for effective and targeted drug deliveries, novel lung therapeutics, non-invasive disease diagnostic methodologies, and exposure health risks evaluations. Numerical simulations are performed on ANSYS Mechanical/CFD platforms, enhanced by in-house C programs.
(* denotes co-first authors)
Feng, Y., Kleinstreuer, C., Nicolas, C. (2016). Computational transport, phase change and deposition analysis of inhaled multicomponent droplet-vapor mixtures in an idealized human upper lung model, Journal of Aerosol Science (In Press)
Chen, X., Zhong, W., Tom, J., Kleinstreuer, C., Feng, Y., He, X. (2016). Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model, Partucuology (In Press)
Feng, Y., Kleinstreuer, C. (2015). Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in a G3-G6 triple bifurcating unit, Journal of Aerosol Science, 80, 58-74
Kleinstreuer, C., Feng, Y.*, Childress, E. M. (2014). Drug-targeting methodologies with applications: a review, World Journal of Clinical Cases, 2(12), 745-756
Feng, Y., Kleinstreuer, C. (2014). Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach, Journal of Aerosol Science, 75, 1-15.
Feng, Y., Kleinstreuer, C. (2013). Analysis of non-spherical particle transport in complex internal shear flows, Physics of Fluids, 25:091904.
Kleinstreuer, C., Feng, Y.* (2013). Lung deposition analyses of inhaled toxic aerosols in conventional and less harmful cigarette smoke: a review, Int. J. Environ. Res. Public Health, 10(9), 4454-4485.
Kleinstreuer, C., Feng, Y.* (2013). Computational analysis of non-spherical particle transport and deposition in shear flow with application to lung aerosol dynamics-a review, Journal of Biomechanical Engineering, 135(2), 021007-1-021007-19.
Kleinstreuer, C., Feng, Y.* (2012). Thermal nanofluid property model with application to nanofluid flow in a parallel-disk system part I: A new thermal conductivity model for nanofluid flow, Journal of Heat Transfer, 134(5), 051002.
Feng, Y., Kleinstreuer, C. (2012). Thermal nanofluid property model with application to nanofluid flow in a parallel-disk system part II: nanofluid flow in a parallel-disk system, Journal of Heat Transfer, 134(5), 051003.
Zhang, Z., Kleinstreuer, C., Feng, Y. (2012). Vapor deposition during cigarette smoke inhalation in subject-specific human airway model, Journal of Aerosol Science, 53, 40-60.
Feng, Y. (2012). Comments on paper: “Transport and deposition on ellipsoidal fibers in low Reynolds number flows” from L. Tian, G. Ahmadi, Z. Wang, P. K. Hopke, Journal of Aerosol Science, Vol. 45, pp. 1-18, Journal of Aerosol Science, 52, 127-128.
Wang, S., Ying, J., Chen, Z. C., Feng, Y. (2011). A new fuzzy self-tuning method for controlling packing pressure of a high-accuracy injection molding machine. Journal of Zhejiang University Engineering Science, 45(8), 1370-1375.
Feng, Y., Kleinstreuer, C. (2010). Nanofluid convective heat transfer in a parallel-disk system, International Journal of Heat and Mass Transfer, 53(21-22), 4619-4628.
Kleinstreuer, C., Feng, Y.* (2010). Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review, Nanoscale Research Letters, 6(229), 1-13.